In a recent study, researchers took 13 blood samples within 24 hours of administering LSD. Bloodĭoctors can also use liquid-liquid extraction and UHPLC-MS/MS to detect LSD in blood samples.
Researchers are uncertain how these findings can help detect LSD use, however. Studies have demonstrated that some inactive byproducts of LSD are present in urine at concentrations 16–43 times higher than LSD. Two techniques that researchers can use to detect LSD in urine are liquid-liquid extraction and ultra-high-performance liquid chromatography-tandem mass spectroscopy (UHPLC-MS/MS). Most routine urine drug tests will not detect LSD. Researchers can use various methods to detect LSD in urine samples, but these techniques are not readily available. In 24 hours, a person excretes only about 1% of LSD unchanged in the urine. When a person takes LSD orally, the liver transforms it into inactive compounds. However, the amounts of these substances that remain in the tissues are still very low. Some researchers have attempted to develop detection methods for the byproducts of LSD. The time that LSD is detectable in the tissues is restrictive, so doctors need to analyze the samples quickly. LSD is also unstable, and the liver breaks it down rapidly.
People only ingest small amounts, so detection methods need to be very sensitive. Researchers experience many challenges when detecting LSD in human tissue samples. The liver breaks down LSD into different chemicals. Once the drug is in the bloodstream, it travels to the brain and other organs, such as the liver. When a person takes LSD orally, the gastrointestinal system absorbs it and channels it into the bloodstream. Share on Pinterest Researchers can use blood and urine tests to detect acid in the system.
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